2008 IdiopathicThrPurCurrConcin...
- (Stasi et al., 2008) ⇒ Rorberto Stasi, Maria Laura Enangelista, Elisa Stipa, Francesco Buccisano, Adriano Venditi, and Sergio Amadori. (2008). “Idiopathic Thrombocytopenic Purpura: Current Concepts in Pathophysiology and Management.” In: Thrombosis and Haemostasis, (99:1).
Subject Headings: Hemopathy; Immunity; Immunology; Platelet; Clinical management; Thrombocytopenia; Treatment; Pathophysiology; Immune thrombocytopenic purpura.
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Abstract
Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count, which is the result of both increased platelet destruction and insufficient platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified. Conventional treatments for ITP aim at reducing platelet destruction, either by immunosuppression or splenectomy. Two new thrombopoietic agents,AMG 531 and eltrombopag, have been used in clinical trials to stimulate platelet production in ITP patients not responsive to standard treatments. These new molecules bear no structural resemblance to thrombopoietin, but still bind and activate the thrombopoietin receptor. This review will focus on the pathophysiology and treatment of ITP in adults, highlighting recent advances in both fields.
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| Author | volume | Date Value | title | type | journal | titleUrl | doi | note | year | |
|---|---|---|---|---|---|---|---|---|---|---|
| 2008 IdiopathicThrPurCurrConcin... | Rorberto Stasi Maria Laura Enangelista Elisa Stipa Francesco Buccisano Adriano Venditi Sergio Amadori | Idiopathic Thrombocytopenic Purpura: Current Concepts in Pathophysiology and Management | http://www.ncbi.nlm.nih.gov/pubmed/18217129 |