Olmesartan Medoxomil

An Olmesartan Medoxomil is an angiotensin II receptor blocker medication that supports blood pressure management through AT1 receptor antagonism.

• Context:
  • It can (typically) act as a prodrug, being converted to olmesartan in the gastrointestinal tract.
  • ...
  • It can range from being a Generic Olmesartan Medication to being a Branded Olmesartan Medication, depending on its drug manufacturer.
  • It can range from being a Standalone Olmesartan Drug to being a Combination Olmesartan Medication (e.g., with hydrochlorothiazide or amlodipine), depending on its therapeutic requirements.
  • ...
  • It can provide Selective AT1 Receptor Antagonism through its benzimidazole structure.
  • It can achieve Once-Daily Dosing due to its drug half-life of approximately 13 hours.
  • It can have Drug Side Effects, such as: dizziness, headache, diarrhea, and back pain.
  • It can cause Serious Adverse Effects including kidney dysfunction, severe hypotension, and angioedema.
  • It can be Patient Contraindicated during Pregnancy and Breastfeeding.
  • It can require Special Monitoring in patients with kidney disease or liver dysfunction.
  • It can have Drug Interactions with Medications affecting the renin-angiotensin system.
  • It can have a Patent Filing of 1991 (by Sankyo).
  • It can have Medical Use Establishment in 2002 (as an antihypertensive drug).
  • ...
• Example(s):
  • Branded Olmesartan Medications, such as:
    • Benicar, which is widely used in the United States.
    • Olmetec, which is common in European markets.
  • Combination Olmesartan Medications, such as:
    • Benicar HCT, which combines olmesartan with hydrochlorothiazide.
    • Azor, which combines olmesartan with amlodipine.
  • ...
• Counter-Example(s):
  • Losartan Drugs, which have different receptor binding kinetics and bioavailability.
  • Valsartan Drugs, which are not prodrugs and have distinct pharmacokinetic profiles.
  • Telmisartan Drugs, which have additional PPAR-gamma activity.
  • Amlodipine Drugs, which work through calcium channel blockade rather than AT1 receptor antagonism.
• See: Angiotensin Receptor Blocker, Antihypertensive Medication, Cardiovascular Drug, Prodrug.

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References

2024

• (Wikipedia, 2024) ⇒ https://en.wikipedia.org/wiki/Olmesartan Retrieved:2024-2-6.
  • Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension). It is taken by mouth. Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine.

    Common side effects include dizziness, headaches, diarrhea, and back pain. Serious side effects may include kidney problems, low blood pressure, and angioedema. Use in pregnancy may harm the fetus and use when breastfeeding is not recommended. It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

    It was patented in 1991 and came into medical use in 2002. It is available as a generic medication. In 2020, it was the 139th most commonly prescribed medication in the United States, with more than 4million prescriptions, ranking 3rd among ARB's after Losartan (9th overall) and Valsartan (123rd overall).

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