1998 StatisticalMethodsforDNASequenc
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- (Braun & Muller, 1998) ⇒ Jerome V Braun, and Hans-Georg Muller. (1998). “Statistical Methods for DNA Sequence Segmentation.” In: Statistical Science.
Subject Headings: Sequence Segmentation; DNA Segmentation.
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Author Keywords
- Statistical genetics; change-point; hidden Markov chain; patchiness; quasideviance; split local polynomials; chromosome banding; bacteriophage λ
Abstract
This article examines methods, issues and controversies that have arisen over the last decade in the effort to organize sequences of DNA base information into homogeneous segments. An array of different models and techniques have been considered and applied. We demonstrate that most approaches can be embedded into a suitable version of the multiple change-point problem, and we review the various methods in this light. We also propose and discuss a promising local segmentation method, namely, the application of split local polynomial fitting. The genome of bacteriophage λ serves as an example sequence throughout the paper.
References
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| Author | volume | Date Value | title | type | journal | titleUrl | doi | note | year | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1998 StatisticalMethodsforDNASequenc | Jerome V Braun Hans-Georg Muller | Statistical Methods for DNA Sequence Segmentation |