Psilocybin Molecule

A Psilocybin Molecule is a tryptamine biomolecule that contains an indole ring linked to an ethylamine substituent.

• AKA: [3-(2-dimethylaminoethyl)-1H-indol-4-yl] dihydrogen phosphate.
• Context:
  • It can be a Prodrug that is converted to Psilocin.
  • It can be a Serotonergic Psychedelic (a lesser harmful recreational drug) (Nutt et al., 2010).
  • It can be contained in a Psilocybin Mushroom.
  • …
• Counter-Example(s):
  • Mescaline.
  • Tetrahydrocannabinol.
  • Lysergic acid diethylamide.
  • MDMA.
• See: Metabolite.

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References

2017

• Luisa Dillner. “Is it safe to take magic mushrooms?."
  • QUOTE: … psilocybin is similar to LSD, but weaker, and mimics serotonin activity in the brain. It reduces brain activity in information transfer centres such as the thalamus, which … tells the brain what movement and sensations it is detecting. Whatever the mechanism, shrooms can make you euphoric, at one with the world and searingly insightful. …

    Studies do not show increased mental health problems from habitual use – unlike the effects of cocaine or cannabis. A BMJ article by psychiatrist James J H Rucker argues that psychedelic drugs may actually help depression and that there is no association with psychosis. A paper in science journal PLoS One found no evidence of flashbacks (such as hallucinations or panic attacks) from sole mushroom use. Mushrooms aren’t habit forming and are far less toxic to our internal organs than heroin or cocaine. ...

2013

• Psychedelics and Mental Health: A Population Study by Teri S. Krebs, Pål-Ørjan Johansen
  • Background: The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline.

2011

• (Wikipedia, 2011) ⇒ http://en.wikipedia.org/wiki/Psilocybin
  • Psilocybin (File:Loudspeaker.svg /ˌsɪləˈsaɪbɪn/ Template:Respell; also known as psilocybine or 4-PO-DMT) is a prodrug for the classical hallucinogen compound psilocin, or 4-HO-DMT (4-hydroxyl-dimethyltryptamine), the active metabolite of psilocybin, responsible for the psychoactive effects of the drug. Both drugs are members of the indole and tryptamine classes.

• (Griffiths et al., 2011) ⇒ Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D. Richards, Una McCann and Robert Jesse. (2011). “Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects.” In: Psychopharmacology, 187(3). doi:10.1007/s00213-011-2358-5

2010

• (Nutt et al., 2010) ⇒ David J. Nutt, Leslie A. King, and Lawrence D. Phillips. (2010). “Drug Harms in the UK: A Multicriteria Decision Analysis.” In: The Lancet. doi:10.1016/S0140-6736(10)61462-6
  • Figure 2: Drugs ordered by their overall harm scores, showing the separate contributions to the overall scores of harms to users and harm to others. The weights after normalisation (0–100) are shown in the key (cumulative in the sense of the sum of all the normalised weights for all the criteria to users, 46; and for all the criteria to others, 54). CW=cumulative weight. GHB=γ hydroxybutyric acid. LSD=lysergic acid diethylamide. File:2010 DrugHarmsintheUKaMulticriteriaD-Figure2.jpg.

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