OprM

An OprM is a Membrane Protein whose primary function is to facilitate the transport of Molecules across a Biological Membrane.

Example(s):
- Pseudomonas Aeruginosa http://www.uniprot.org/uniprot/Q51487
- PMID 10889211: “The outer membrane subunit OprM of the multicomponent efflux pump of Pseudomonas aeruginosa has been assumed to form a transmembrane xenobiotic exit channel across the outer membrane . We challenged this hypothesis to clarify the underlying ambiguity by manipulating the amino-terminal signal sequence of the OprM protein of the MexAB-OprM efflux pump in P. aeruginosa”
Counter-Example(s):
- PMID10639352: “Indeed, the 50-kDa OMP of these S. maltophilia MDR strains reacted with antibody to OprM, the outer membrane component of the MexAB-OprM MDR efflux system of P. aeruginosa. Similarly, a ca. 110-kDa cytoplasmic membrane protein of these MDR strains also reacted with antibody to the MexB component of the P. aeruginosa pump.”
See: Pseudomonas Aeruginosa.

References

(Wikipedia, 2009) ⇒ http://en.wikipedia.org/wiki/OPRM
- The μ opioid receptors (MOR) are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. The prototypical μ receptor agonist is the opium alkaloid morphine; μ (mu) refers to morphine.