NADH Dehydrogenase
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A NADH Dehydrogenase is the first Enzyme within the Mitochondrial Electron Transport Chainand is located in the Inner Mitochondrial Membrane that Catalyzes the transfer of electrons from NADH to Coenzyme Q.
- AKA: Cytochrome C Reductase, Type 1 Dehydrogenase, Beta-NADH Dehydrogenase Dinucleotide, Diaphorase, Dihydrocodehydrogenase I Dehydrogenase, Dihydronicotinamide Adenine Dinucleotide Dehydrogenase, Diphosphopyridine Diaphorase, DPNH Diaphorase, NADH diaphorase, NADH Hydrogenase, NADH Oxidoreductase, NADH-Menadione Oxidoreductase, Reduced Diphosphopyridine Nucleotide Diaphorase.
- Context:
- It can be identified by the following database entries and numerical idenfiers:
- It can be catalysed by following chemical reaction :
- [math]\displaystyle{ NADH + H^+\; +\; acceptor \rightleftharpoons NAD^+\; +\; reduced \;acceptor }[/math]
- Example(s):
- Bacillus caldotenax http://www.uniprot.org/uniprot/P05644
- PMID 6166606: NADH dehydrogenase [EC 1.6.99.3] in membranes of Bacillus caldotenax was solubilized with sodium N-lauroylsarcosinate and purified 50-fold from membranes to 75-80% homogeneity, as judged by SDS-polyacrylamide gel electrophoresis.
- …
- Counter-Example(s):
- See: Mitochondria, Chemical Reaction, Enzyme, List of Enzymes, Catalysis.
References
2019
- (Wikipedia, 2019) ⇒ https://en.wikipedia.org/wiki/NADH_dehydrogenase Retrieved:2019-2-10.
- NADH dehydrogenase (cytochrome c reductase, type 1 dehydrogenase, beta-NADH dehydrogenase dinucleotide, diaphorase, dihydrocodehydrogenase I dehydrogenase, dihydronicotinamide adenine dinucleotide dehydrogenase, diphosphopyridine diaphorase, DPNH diaphorase, NADH diaphorase, NADH hydrogenase, NADH oxidoreductase, NADH-menadione oxidoreductase, reduced diphosphopyridine nucleotide diaphorase) is an enzyme with systematic name NADH:acceptor oxidoreductase. This enzyme catalyses the following chemical reaction
[math]\displaystyle{ NADH + H^+\; +\; acceptor \rightleftharpoons NAD^+\; +\; reduced \;acceptor }[/math]
NADH dehydrogenase is a flavoprotein that contains iron-sulfur centres.
NADH dehydrogenase is used in the electron transport chain for generation of ATP.
- NADH dehydrogenase (cytochrome c reductase, type 1 dehydrogenase, beta-NADH dehydrogenase dinucleotide, diaphorase, dihydrocodehydrogenase I dehydrogenase, dihydronicotinamide adenine dinucleotide dehydrogenase, diphosphopyridine diaphorase, DPNH diaphorase, NADH diaphorase, NADH hydrogenase, NADH oxidoreductase, NADH-menadione oxidoreductase, reduced diphosphopyridine nucleotide diaphorase) is an enzyme with systematic name NADH:acceptor oxidoreductase. This enzyme catalyses the following chemical reaction
2011
- (GO, 2011) ⇒ http://www.informatics.jax.org/vocab/gene_ontology/GO:0030964
- Ontology: cellular component
- Synonyms
- narrow: NADH dehydrogenase complex (plastoquinone)
- narrow: NADH dehydrogenase complex (plastoquinone) (sensu Cyanobacteria)
- narrow: NADH dehydrogenase complex (quinone) (sensu Bacteria)
- narrow: NADH dehydrogenase complex (ubiquinone) (sensu Bacteria)
- narrow: NADH:plastoquinone reductase complex
- narrow: plastid NADH dehydrogenase complex (plastoquinone)
- alt_id: GO:0030025
- alt_id: GO:0030966
- alt_id: GO:0031675
- alt_id: GO:0031677
- alt_id: GO:0031678
- alt_id: GO:0045280
- exact: Complex I
- Definition
- An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone. [source: GOC:mah]