Major Histocompatibility Complex Class I-Related Protein
Jump to navigation
Jump to search
A Major Histocompatibility Complex Class I-Related Protein is a protein.
- Example(s):
- Human MR1 Protein, which is produced by a Human MR1 gene.
- See: Histocompatibility, Endoplasmic Reticulum, Riboflavin, Mucosal Associated Invariant T Cell.
References
2020
- (Wikipedia, 2020) ⇒ https://en.wikipedia.org/wiki/Major_histocompatibility_complex,_class_I-related Retrieved:2020-1-21.
- Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene. Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366. The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to mucosal associated invariant T cells for activation. Within cells, MR1 is mostly stored inside the endoplasmic reticulum, where the binding of bacterial riboflavin-related molecules to MR1 occurs, causing it to be sent to the cell surface for presentation. A T-cell receptor for the MR1 surface coat protein shows potential for cancer treatment.