Heme Molecule
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A Heme Molecule is a biomolecule that consists of iron cation bound at the center of the conjugate base of the porphyrin, as well as other ligands attached to the "axial sites" of the iron.
- Context:
- It can be a member of a Hemeprotein.
- …
- Example(s):
- See: Haemoglobin, Coordination Complex, Porphyrin, Tetradentate Ligand, Metalloprotein, Prosthetic Group.
References
2020
- (Wikipedia, 2020) ⇒ https://en.wikipedia.org/wiki/heme Retrieved:2020-10-9.
- Heme (American English) or haem (British English ) is a substance precursive to haemoglobin, which is necessary to bind oxygen in the bloodstream. Haem is biosynthesized in both the bone marrow and the liver. In microbiological terms, haem is coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands. [1] Among the metalloporphyrins deployed by metalloproteins as prosthetic groups, heme is one of the most widely used and defines a family of proteins known as hemoproteins. Hemes are most commonly recognized as components of hemoglobin, the red pigment in blood, but are also found in a number of other biologically important hemoproteins such as myoglobin, cytochromes, catalases, heme peroxidase, and endothelial nitric oxide synthase.
The word haem is derived from Greek haima meaning "blood".
- Heme (American English) or haem (British English ) is a substance precursive to haemoglobin, which is necessary to bind oxygen in the bloodstream. Haem is biosynthesized in both the bone marrow and the liver. In microbiological terms, haem is coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands. [1] Among the metalloporphyrins deployed by metalloproteins as prosthetic groups, heme is one of the most widely used and defines a family of proteins known as hemoproteins. Hemes are most commonly recognized as components of hemoglobin, the red pigment in blood, but are also found in a number of other biologically important hemoproteins such as myoglobin, cytochromes, catalases, heme peroxidase, and endothelial nitric oxide synthase.
- ↑ A standard biochemistry text defines heme as the "iron-porphyrin prosthetic group of heme proteins"(Nelson, D. L.; Cox, M. M. “Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. .)