G Protein-Coupled Receptors Database

A G Protein-Coupled Receptors Database is a Molecular Class-Specific Information System that automatically collects, updates and retrieves biological data on G Protein-coupled Receptors.

• AKA: GPCRDB.
  • …
• Example(s):
  • https://github.com/protwis/protwis
• Counter-Example(s):
  • NucleaRDB,
• See: Biological Database, Knowledge Database , Phylogenetic Tree ,G Protein-coupled Receptor, Nuclear Hormone Receptor, Genetic Mutation.

---

---

References

2019a

• (Wikipedia, 2019) ⇒ https://en.wikipedia.org/wiki/G_protein-coupled_receptors_database Retrieved:2019-1-20.
  • GPCRdb contains data, web tools and diagrams for G protein-coupled receptors (GPCRs). It stores a manual annotation of all GPCR crystal structures, the largest collections of receptor mutants and reference sequence alignments. The tools run directly in the web browser allowing for swift analysis of structures, sequence similarities, receptor relationships, homology models, drug trends, genetic variants and ligand target profiles. Diagrams illustrate receptor sequences (snake-plot and helix box diagrams) and relationships (phylogenetic trees).

2019b

• (gpcrdb.org, 2019) ⇒ http://docs.gpcrdb.org/about.html#about-gpcrdb Retrieved:2019-1-20.
  • QUOTE: GPCRdb offers reference data and easy-to-use web tools and diagrams for a multidisciplinary audience investigating GPCR function, drug design or evolution. It stores a manual annotation of all GPCR crystal structures, the largest collections of receptor mutants and reference sequence alignments. The tools run directly in the web browser allowing for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Diagrams illustrate receptor sequences (snake-plot and helix box diagrams) and relationships (phylogenetic trees). A visual overview can be seen in the GPCRdb poster.

2011

• (Vroling et al., 2011) ⇒ Bas Vroling, Marijn Sanders, Coos Baakman, Annika Borrmann, Stefan Verhoeven, Jan Klomp, Laerte Oliveira, Jacob de Vlieg, and Gert Vriend. (2011). “GPCRDB: Information System for G Protein-coupled Receptors.” In: Nucleic Acids Research, 39(1). doi:10.1093/nar/gkq1009
  • ABSTRACT: The GPCRDB is a Molecular Class-Specific Information System (MCSIS) that collects, combines, validates and disseminates large amounts of heterogeneous data on G protein-coupled receptors (GPCRs). The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data such as multiple sequence alignments and homology models. The GPCRDB provides access to the data via a number of different access methods. It offers visualization and analysis tools, and a number of query systems. The data is updated automatically on a monthly basis. The GPCRDB can be found online at http://www.gpcr.org/7tm/.

2004

• (Horn et al., 2004) ⇒ Florence Horn, Anthony L. Lau, and Fred E. Cohen. (2004). “Automated Extraction of Mutation Data from the Literature: Application of MuteXt to G protein-coupled receptors and nuclear hormone receptors.” In: Bioinformatics, 20(4).
  • QUOTE: We are involved in the Molecular Class-Specific Information System (MCSIS) project, a collaborative effort to design and automate the maintenance of protein family databases. The first two databases, the GPCRDB and NucleaRDB, are focused on G protein-coupled receptors (GPCRs) and nuclear hormone receptors (NRs), respectively. The main aim of the MCSIS project is to gather heterogeneous data from across a variety of electronic and literature sources in order to draw new inferences about the target protein families.

---