DNA Replication
A DNA Replication is a biological process that produces two identical copies of a DNA molecule.
- AKA: DNA Amplification.
- Context:
- It can range from being a natural DNA Replication to being an In-Vitro DNA Replication.
- …
- Example(s):
- Counter-Example(s):
- See: Abiogenesis, Molecular Biology, DNA Replication Stress, DNA, Life, Semiconservative Replication, Proofreading (Biology), Epigenetics, Genome, Autopoiesis.
References
2023
- (ChatGPT-OpenAI, 2023) ⇒ https://chat.openai.com/chat Retrieved 2023-03-19.
- Q: What is DNA Replication?
- A: DNA replication is the process by which a cell makes an identical copy of its DNA. This process is crucial for cell division, growth, and repair. DNA replication occurs during the S phase of the cell cycle, in which the DNA in the cell's nucleus is duplicated before the cell divides.
The process of DNA replication involves several steps, including:
- Unwinding and separation of the double helix: The two strands of DNA are separated by breaking the hydrogen bonds between them.
- Priming: The DNA primase enzyme synthesizes short RNA primers that provide a starting point for DNA synthesis.
- Elongation: The DNA polymerase enzyme adds nucleotides to the growing DNA strand, using the template strand as a guide.
- Proofreading: The DNA polymerase checks for errors and corrects any mistakes in the sequence.
- Termination: When the DNA replication is complete, the newly synthesized DNA strands are separated and the cell can proceed to divide.
- DNA replication is a complex process that requires the coordinated action of many enzymes and proteins. Any errors or mutations that occur during replication can have serious consequences, such as genetic diseases or cancer. Therefore, cells have evolved sophisticated mechanisms to ensure the accuracy and fidelity of DNA replication.
2022
- (Wikipedia, 2022) ⇒ https://en.wikipedia.org/wiki/DNA_replication Retrieved:2022-10-13.
- In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential.<PDNA is made up of > DNA is made up of a double helix of two complementary strands. The double helix describes the appearance of a double-stranded DNA which is thus composed of two linear strands that run opposite to each other and twist together to form. During replication, these strands are separated. Each strand of the original DNA molecule then serves as a template for the production of its counterpart, a process referred to as semiconservative replication. As a result of semi-conservative replication, the new helix will be composed of an original DNA strand as well as a newly synthesized strand. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.[1]
In a cell, DNA replication begins at specific locations, or origins of replication, in the genome which contains the genetic material of an organism. Unwinding of DNA at the origin and synthesis of new strands, accommodated by an enzyme known as helicase, results in replication forks growing bi-directionally from the origin. A number of proteins are associated with the replication fork to help in the initiation and continuation of DNA synthesis. Most prominently, DNA polymerase synthesizes the new strands by adding nucleotides that complement each (template) strand. DNA replication occurs during the S-stage of interphase.
DNA replication (DNA amplification) can also be performed in vitro (artificially, outside a cell). DNA polymerases isolated from cells and artificial DNA primers can be used to start DNA synthesis at known sequences in a template DNA molecule. Polymerase chain reaction (PCR), ligase chain reaction (LCR), and transcription-mediated amplification (TMA) are examples. In March 2021, researchers reported evidence suggesting that a preliminary form of transfer RNA, a necessary component of translation, the biological synthesis of new proteins in accordance with the genetic code, could have been a replicator molecule itself in the very early development of life, or abiogenesis.[2] [3]
- In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential.<PDNA is made up of > DNA is made up of a double helix of two complementary strands. The double helix describes the appearance of a double-stranded DNA which is thus composed of two linear strands that run opposite to each other and twist together to form. During replication, these strands are separated. Each strand of the original DNA molecule then serves as a template for the production of its counterpart, a process referred to as semiconservative replication. As a result of semi-conservative replication, the new helix will be composed of an original DNA strand as well as a newly synthesized strand. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.[1]
- ↑ Imperfect DNA replication results in mutations.
- ↑ Kühnlein A, Lanzmich SA, Braun D (March 2021). "tRNA sequences can assemble into a replicator". eLife. 10: e63431. doi:10.7554/eLife.63431. PMC 7924937. PMID 33648631.
- ↑ Maximilian L (3 April 2021). "Solving the Chicken-and-the-Egg Problem – "A Step Closer to the Reconstruction of the Origin of Life". SciTechDaily. Retrieved 3 April 2021.