Cyclic Guanosine Monophosphate-Specific Phosphodiesterase Type 5 (PDE5) Enzyme
A Cyclic Guanosine Monophosphate-Specific Phosphodiesterase Type 5 (PDE5) Enzyme is a phosphodiesterase (PDE) enzyme.
- AKA: CGMP-Specific Phosphodiesterase Type 5.
- Context:
- It can be targeted by a PD5 Inhibitor, such as Sildenafil.
- …
- See: Zaprinast, Cyclic Adenosine Monophosphate, Cyclic Guanosine Monophosphate, Theophylline, Tadalafil.
References
2021
- (Wikipedia, 2021) ⇒ https://en.wikipedia.org/wiki/CGMP-specific_phosphodiesterase_type_5 Retrieved:2021-9-3.
- cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina. It has also been recently discovered to play a vital role in the cardiovascular system.
The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis.
The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side-effects attributed to nonselective inhibitors such as theophylline.
Sildenafil, vardenafil, tadalafil, and avanafil are PDE5 inhibitors that are significantly more potent and selective than zaprinast and other early PDE5 inhibitors.
- cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina. It has also been recently discovered to play a vital role in the cardiovascular system.