Salbutamol

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A Salbutamol is a beta2-adrenergic receptor agonist.



References

2015

  • (Wikipedia, 2015) ⇒ http://en.wikipedia.org/wiki/Salbutamol Retrieved:2015-11-11.
    • Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD). It is marketed as Ventolin among other brand names. Salbutamol was the first selective β2-receptor agonist to be marketed in 1968. It was first sold by Allen & Hanburys (UK) under the brand name Ventolin, and has been used for the treatment of asthma ever since. It was approved for use in the US by the Food and Drug Administration (FDA) in May 1982. [1] The drug is usually manufactured and distributed as the sulfate salt salbutamol sulfate. Salbutamol is mostly taken by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered-dose inhaler (MDI), nebulizer, or other proprietary delivery devices. In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. Mean duration of effect is roughly 2 hours. [2] It can also be given intravenously. Salbutamol is also available in oral form (tablets, syrup). It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. Compliance with the Montreal Protocol, which requires the banning of the use of ozone-layer depleting CFCs, has caused the price of inhalers, however, to increase as much as ten-fold as generics were forced off the market from 2009 to 2013 by new patents obtained by pharmaceutical companies for non-CFC delivery systems.
  1. MedicineNet, Inc. http://www.medicinenet.com/albuterol/article.htm
  2. Measured by a 15% increase from baseline in FEV1.

2013