Learning Models of Biological Sequences
- See: Biological Sequence, Biological Sequence Analysis, Biomedical Informatics , DNA, Protein Sequence, Molecular Biology.
References
2017
- (Noble & Leslie, 2017) ⇒ William Stafford Noble; and Christina Leslie. (2017). "Learning Models of Biological Sequences". In: (Sammut & Webb, 2017). DOI: 10.1007/978-1-4899-7687-1_468
- QUOTE: Fundamentally, the motivation for building models of biological sequences is to understand the molecular mechanisms of the cell and the molecular basis for human disease. Each subheading below describes a different type of model, each of which attempts to capture a different facet of the underlying biology. All of these models, ultimately, aim to uncover either evolutionary or functional relationships among sequences.
Although DNA and protein sequences were available in small numbers as early as the 1950s, a significant number of sequences were not available until the 1980s. Most of the advances in model development started in the 1990s, with the exception of phylogenetic models, which were already being developed in the 1970s.
- QUOTE: Fundamentally, the motivation for building models of biological sequences is to understand the molecular mechanisms of the cell and the molecular basis for human disease. Each subheading below describes a different type of model, each of which attempts to capture a different facet of the underlying biology. All of these models, ultimately, aim to uncover either evolutionary or functional relationships among sequences.