The Systolic Blood Pressure Intervention Trial (SPRINT)
A The Systolic Blood Pressure Intervention Trial (SPRINT) is a randomized clinical trial that aimed to determine whether intensive blood pressure control is more effective than standard blood pressure control in reducing the risk of cardiovascular disease and other complications in older adults.
- Context:
- It can be associated with NCT01206062 [1].
- It can have a Clinical Trial Study Outcome that,
- The intensive treatment group had a 25% lower risk of the primary composite outcome (myocardial infarction, stroke, and cardiovascular death) compared to the standard treatment group.
- The intensive treatment group had a 27% lower risk of all-cause mortality compared to the standard treatment group.
- The intensive treatment group had a 43% lower risk of heart failure compared to the standard treatment group.
- The intensive treatment group had a lower risk of kidney disease and cognitive decline compared to the standard treatment group.
- ...
- See: Systolic Blood Pressure.
References
2023
- chat
- Q: Describe the research protocol of The Systolic Blood Pressure Intervention Trial (SPRINT).
- A: The Systolic Blood Pressure Intervention Trial (SPRINT) was a randomized controlled trial that aimed to determine whether intensive blood pressure control is more effective than standard blood pressure control in reducing the risk of cardiovascular disease and other complications in older adults.
The study included 9,361 participants who were at least 50 years of age with systolic blood pressure of 130 mm Hg or higher, and at least one additional cardiovascular risk factor, such as diabetes, chronic kidney disease, or prior cardiovascular disease. Participants were randomly assigned to one of two groups:
- Intensive treatment group: Participants in this group aimed to achieve a systolic blood pressure of less than 120 mm Hg through the use of multiple medications and lifestyle modifications.
- Standard treatment group: Participants in this group aimed to achieve a systolic blood pressure of less than 140 mm Hg through the use of one or more medications and lifestyle modifications.
- The primary outcome of the study was the composite of myocardial infarction, stroke, and cardiovascular death. Secondary outcomes included all-cause mortality, kidney disease, and cognitive decline. Participants were followed for a median of 3.26 years.
The study was conducted at various sites across the United States, and participants were seen at regular intervals for blood pressure measurements, laboratory tests, and other assessments. Participants were also asked to complete questionnaires and diaries to document any adverse events and to record any changes in their lifestyle or medication regimen.
The study was funded by the National Institutes of Health and the results were published in the New England Journal of Medicine in 2015.
2023
- chat
- Q: What was the outcome of The Systolic Blood Pressure Intervention Trial (SPRINT)?
- A: The Systolic Blood Pressure Intervention Trial (SPRINT) found that intensive blood pressure control, aiming for a systolic blood pressure of less than 120 mm Hg, was associated with a significantly lower risk of cardiovascular disease and all-cause mortality, compared to standard blood pressure control, aiming for a systolic blood pressure of less than 140 mm Hg.
Specifically, the study found that:
- The intensive treatment group had a 25% lower risk of the primary composite outcome (myocardial infarction, stroke, and cardiovascular death) compared to the standard treatment group.
- The intensive treatment group had a 27% lower risk of all-cause mortality compared to the standard treatment group.
- The intensive treatment group had a 43% lower risk of heart failure compared to the standard treatment group.
- The intensive treatment group had a lower risk of kidney disease and cognitive decline compared to the standard treatment group.
- It's important to note that the study also found that intensive blood pressure control was associated with a higher risk of adverse events such as hypotension, electrolyte abnormalities, and acute kidney injury, and that these risks need to be balanced against the potential benefits of intensive treatment in individual patients.
The results of SPRINT trial have changed the hypertension treatment guidelines and now many guidelines recommend a systolic blood pressure goal of < 130 mm Hg in older adults. However, more research is needed to determine whether intensive treatment is safe and effective for all older adults with hypertension.
2023
- chat
- Q: Where can I find the clinical study report of The Systolic Blood Pressure Intervention Trial (SPRINT)?
- A: You can find the clinical study report of The Systolic Blood Pressure Intervention Trial (SPRINT) in various sources. One way to find it is to search for the study in ClinicalTrials.gov, which is a publicly available database that provides information about clinical studies. On ClinicalTrials.gov, you can find the study by searching for its identifier, NCT01206062, and then click on the "Results" tab.
Another way to find the clinical study report is to look for it in a scientific journal that published the study's results. The study was published in the New England Journal of Medicine, you can find the report by searching for the article title on the journal's website.
Additionally, you can also request the study report from the National Institutes of Health (NIH) as it was funded by them.
Please note that the study report is a detailed document that provides information about the study's design, methods, results, and conclusions, and it may not be easily understandable for someone without a scientific background. If you need help understanding the report, you can ask for help from a healthcare professional or a researcher in the field.