Protein-Protein Interaction (PPI) Event
A Protein-Protein Interaction (PPI) Event is a biological event between Two or more Proteins.
- Context:
- It can be represented in a PPI Database.
- It can be a member of a Protein Interaction Network.
- ...
- Example(s):
- A Yeast PPI.
- A Human PPI.
- An Arabidopsis PPI.
- a ProteinOf Relation.
- ...
- Counter-Example(s):
- See: Genomic Database, Protein-Protein Interaction Task, Biochemical Cascade, Interactome, Protein–Protein Interaction Investigation Method.
References
2023
- (Wikipedia, 2023) ⇒ https://en.wikipedia.org/wiki/Protein–protein_interaction Retrieved:2023-6-22.
- Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.
Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are carried out by molecular machines that are built from numerous protein components organized by their PPIs. These physiological interactions make up the so-called interactomics of the organism, while aberrant PPIs are the basis of multiple aggregation-related diseases, such as Creutzfeldt–Jakob and Alzheimer's diseases.
PPIs have been studied with many methods and from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks[1] – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and molecular etiology of disease, as well as the discovery of putative protein targets of therapeutic interest.
- Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.
- ↑ Cite error: Invalid
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