Vasopressin Molecule
A Vasopressin Molecule is a neurotransmitter that ...
- Example(s):
- See: Oxytocin, Prairie Vole, Cardiomyocytes, Antihypotensive Agent, Supraoptic Nucleus, Paraventricular Nucleus of Hypothalamus, Vasopressin Receptor 1A, Vasopressin Receptor 1B, Vasopressin Receptor 2, Oxytocin Receptor, Felypressin.
References
2022
- (Wikipedia, 2022) ⇒ https://en.wikipedia.org/wiki/Vasopressin Retrieved:2022-10-22.
- Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure. [1]
A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress. Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.
It has a very short half-life, between 16 and 24 minutes.[2]
- Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure. [1]
2013
- Zoe Cormier. (2013) "Gene switches make prairie voles fall in love." In: Nature | News, July 2, 2013
- QUOTE: ... Previous studies have shown that the neurotransmitters oxytocin and vasopressin play a major part in inducing and regulating the formation of the pair bond. Monogamous prairie voles are known to have higher levels of receptors for these neurotransmitters than do voles who have yet to mate; and when otherwise promiscuous montane voles (M. montanus) are dosed with oxytocin and vasopressin, they adopt the monogamous behaviour of their prairie cousins.
Because behaviour seemed to play an active part in changing the neurobiology of the animals, scientists suspected that epigenetic factors were involved. These are chemical modifications to the chromosomes that affect how genes are transcribed or suppressed, as opposed to changes in the gene sequences themselves.
- QUOTE: ... Previous studies have shown that the neurotransmitters oxytocin and vasopressin play a major part in inducing and regulating the formation of the pair bond. Monogamous prairie voles are known to have higher levels of receptors for these neurotransmitters than do voles who have yet to mate; and when otherwise promiscuous montane voles (M. montanus) are dosed with oxytocin and vasopressin, they adopt the monogamous behaviour of their prairie cousins.
2022
- (Wikipedia, 2022) ⇒ https://en.wikipedia.org/wiki/Vasopressin Retrieved:2022-9-15.
- {{drugbox
| Watchedfields = changed
| verifiedrevid =
| drug_name =
| IUPAC_name = 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide
| synonyms= Antidiuretic hormone (ADH); arginine vasopressin (AVP); argipressin
| image = Vasopressin_labeled.png
| width = 250px
| image2 = Arginine_vasopressin3d.png
| pronounce = | source_tissues = Supraoptic nucleus; paraventricular nucleus of hypothalamus
| target_tissues = System-wide
| receptors = V1A, V1B, V2, OXTR
| agonists = Felypressin, desmopressin
| antagonists = Diuretics
| bioavailability =
| protein_bound = 1%
| metabolism = Predominantly in the liver and kidneys
| elimination_half-life = 10–20 minutes
| excretion = Urine
| ATC_prefix = H01
| ATC_suffix = BA01
| IUPHAR_ligand = 2168
| CAS_number_Ref = | CAS_number = 11000-17-2
| PubChem = 644077
| DrugBank_Ref = | DrugBank = DB00067
| ChemSpiderID_Ref = | ChemSpiderID = 559126
| UNII_Ref = | UNII = Y87Y826H08
| KEGG_Ref = | KEGG = D00101
| ChEBI_Ref = | ChEBI = 9937
| ChEMBL_Ref = | ChEMBL = 373742
| PDB_ligand =
| C=46 | H=65 | N=15 | O=12 | S=2
| molecular_weight =
| SMILES = c1ccc(cc1)C[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
| StdInChI_Ref = | StdInChI = 1S/C46H65N15O12S2
/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
| StdInChIKey_Ref = | StdInChIKey = KBZOIRJILGZLEJ-LGYYRGKSSA-N
| density = 1.6±0.1
|alt=|caption=|type=|MedlinePlus=|legal_status=|licence_EU=|pregnancy_AU=|pregnancy_US=|pregnancy_category=|licence_US=}}
Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure. [1]
A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress. Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.
It has a very short half-life, between 16 and 24 minutes.[2]
- {{drugbox