Adderall Medicine

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An Adderall Medicine is a combination drug composed of amphetamine and dextroamphetamine.



References

2024

Adderall is generally well-tolerated and effective in treating symptoms of ADHD and narcolepsy. At therapeutic doses, Adderall causes emotional and cognitive effects such as euphoria, change in sex drive, increased wakefulness, and improved cognitive control. At these doses, it induces physical effects such as a faster reaction time, fatigue resistance, and increased muscle strength. In contrast, much larger doses of Adderall can impair cognitive control, cause rapid muscle breakdown, provoke panic attacks, or induce a psychosis (e.g., paranoia, delusions, hallucinations). The side effects of Adderall vary widely among individuals, but most commonly include insomnia, dry mouth, loss of appetite, and weight loss. The risk of developing an addiction or dependence is insignificant when Adderall is used as prescribed at fairly low daily doses, such as those used for treating ADHD; however, the routine use of Adderall in larger daily doses poses a significant risk of addiction or dependence due to the pronounced reinforcing effects that are present at high doses. Recreational doses of amphetamine are generally much larger than prescribed therapeutic doses, and carry a far greater risk of serious adverse effects.[sources 1]

The two amphetamine enantiomers that compose Adderall (levoamphetamine and dextroamphetamine) alleviate the symptoms of ADHD and narcolepsy by increasing the activity of the neurotransmitters norepinephrine and dopamine in the brain, which results in part from their interactions with human trace amine-associated receptor 1 (hTAAR1) and vesicular monoamine transporter 2 (VMAT2) in neurons. Dextroamphetamine is a more potent Central nervous system (Template:Abbr) stimulant than levoamphetamine, but levoamphetamine has slightly stronger cardiovascular and peripheral effects and a longer elimination half-life than dextroamphetamine. The levoamphetamine component of Adderall has been reported to improve the treatment response in some individuals relative to dextroamphetamine alone. Adderall's active ingredient, amphetamine, shares many chemical and pharmacological properties with the human trace amines, particularly phenethylamine and N-methylphenethylamine, the latter of which is a positional isomer of amphetamine.[sources 2] In 2021, Adderall was the seventeenth most commonly prescribed medication in the United States, with more than 30Template:Nbspmillion prescriptions.[26][27] Template:TOC limit

  1. 1.0 1.1 Template:Cite news
  2. "National Drug Code Amphetamine Search Results". United States Food and Drug Administration. http://www.accessdata.fda.gov/scripts/cder/ndc/results.cfm?beginrow=1&numberperpage=160&searchfield=amphetamine&searchtype=ActiveIngredient&OrderBy=ProprietaryName. Retrieved 16 December 2013. 
  3. 3.0 3.1 3.2 "Amphetamine, past and present--a pharmacological and clinical perspective". Journal of Psychopharmacology 27 (6): 479–496. June 2013. doi:10.1177/0269881113482532. PMC 3666194. PMID 23539642. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3666194. 
  4. "Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers". Psychopharmacology 191 (3): 669–677. April 2007. doi:10.1007/s00213-006-0550-9. PMID 17031708. 
  5. "Pharmacology". Arbor Pharmaceuticals, LLC. https://www.evekeo.com/hcp/evekeo-pharmacology. Retrieved 2 May 2020. 
  6. "Prescribing Information & Medication Guide". Arbor Pharmaceuticals LLC. https://zenzedi.com/docs/PIandMedicationGuide.pdf. Retrieved 2 May 2020. 
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  16. Encyclopedia of Psychopharmacology. Berlin, Germany; London, England: Springer. 2010. p. 78. ISBN 9783540686989. 
  17. "Monoamine transporters and psychostimulant addiction". Biochemical Pharmacology 75 (1): 196–217. January 2008. doi:10.1016/j.bcp.2007.08.003. PMID 17825265. 
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  21. Broadley KJ (March 2010). "The vascular effects of trace amines and amphetamines". Pharmacology & Therapeutics 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186. 
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  26. "The Top 300 of 2021". https://clincalc.com/DrugStats/Top300Drugs.aspx. Retrieved 14 January 2024. 
  27. "Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate - Drug Usage Statistics". https://clincalc.com/DrugStats/Drugs/DextroamphetamineDextroamphetamineSaccharateAmphetamineAmphetamineAspartate. Retrieved 14 January 2024. 


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