2009 TheAutomationofScience

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Subject Headings: Scientific Discovery.

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Abstract

The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot ScientistAdam, which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.

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 AuthorvolumeDate ValuetitletypejournaltitleUrldoinoteyear
2009 TheAutomationofScienceMaria Liakata
Larisa Soldatova
Jem Rowland
Michael Young
Wayne Aubrey
Emma Byrne
Magdalena Markham
Pinar Pir
Ross D. King
Stephen G. Oliver
The Automation of Science2009